Hepatitis B exposure postexposure prophylaxis (HBIG) should be given as soon as possible, preferably within how long after exposure?

• A. 7 days
• B. 24 hours
• C. 2 weeks
• D. 1 month

Answer: (B)

HBIG provides immediate, passive immunity that helps neutralize the virus right after exposure, while the vaccine helps the body build its own long-term protection. Because the antibodies from HBIG act right away, giving them as soon as possible after exposure offers the best chance to prevent hepatitis B infection. The option that represents the optimal timing is within 24 hours of exposure. The earlier this is done, the better the outcome, whereas delaying beyond the initial hours reduces effectiveness. If the person is not vaccinated or not up to date, HBIG is given along with the hepatitis B vaccine series to establish both immediate and future protection.