Which statement about the liver’s role in coagulation is correct?

• A. The liver plays an important role in coagulation
• B. The liver has no role in coagulation
• C. Coagulation factors are produced by the spleen
• D. Coagulation is independent of liver function

Answer: (A)

Coagulation depends on the liver’s ability to synthesize most of the clotting factors (such as prothrombin factor II, and factors VII, IX, and X) and the natural anticoagulants (like protein C, protein S, and antithrombin). When the liver is functioning well, these proteins are produced in the right amounts to support normal clot formation and regulation. If liver disease or damage is present, production of these factors falls, leading to a higher risk of abnormal bleeding and longer clotting times (for example, an elevated INR). Therefore, stating that the liver plays an important role in coagulation accurately reflects this central connection.

The other ideas don’t fit: coagulation factors are not produced by the spleen, and coagulation is not independent of liver function. The liver’s synthetic role is key to both clot formation and regulation.