Which statement is true about acute vs chronic hepatitis infections?

• A. Hepatitis A and E can cause acute infections only
• B. Hepatitis B, C, and D can cause both acute and chronic infections
• C. Hepatitis A, B, and C all cause chronic infections
• D. Hepatitis E always becomes chronic

Answer: (B)

Understanding which hepatitis viruses can become chronic versus staying acute is essential. Hepatitis A and E are typically self-limited and do not lead to chronic infection in healthy individuals. In contrast, hepatitis B and hepatitis C commonly persist as chronic infections, with long-term liver risks. Hepatitis D is a bit different: it can cause chronic infection, but only in the presence of hepatitis B (a coinfection or superinfection with B). So the statement that hepatitis B, C, and D can all cause both acute and chronic infections captures the real pattern: B and C routinely can become chronic, and D can become chronic when it occurs with B. The other options misstate the typical courses, since A and E are not chronic in most cases, and E chronic cases are rare and usually linked to immunosuppression.